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A prescription medicine called tapentadol is used to treat moderate to severe pain. Although it has a distinct dual mechanism of action, it is a member of the class of medications known as opioid analgesics. Tapentadol also prevents the reuptake of norepinephrine, a neurotransmitter implicated in pain communication, in contrast to conventional opioids, which solely function by attaching to opioid receptors in the brain and spinal cord.